Journal article
A brain-derived neurotrophic factor-based p75NTR peptide mimetic ameliorates experimental autoimmune neuritis induced axonal pathology and demyelination
DG Gonsalvez, G Tran, JL Fletcher, RA Hughes, S Hodgkinson, RJ Wood, SW Yoo, M De Silva, WW Agnes, C McLean, P Kennedy, TJ Kilpatrick, SS Murray, J Xiao
Eneuro | SOC NEUROSCIENCE | Published : 2017
Abstract
Axonal damage and demyelination are major determinants of disability in patients with peripheral demyelinating neuropathies. The neurotrophin family of growth factors are essential for the normal development and myelination of the peripheral nervous system (PNS), and as such are potential therapeutic candidates for ameliorating axonal and myelin damage. In particular, BDNF promotes peripheral nerve myelination via p75 neurotrophin receptor (p75NTR) receptors. Here, we investigated the therapeutic efficacy of a small structural mimetic of the region of BDNF that binds to p75NTR (cyclo-DPAKKR) in experimental autoimmune neuritis (EAN), an established animal model of peripheral demyelinating ne..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council Project Grant APP1058647 (to X.J.), The University of Melbourne Research Grant Support Scheme, and Melbourne Research Career Interruption Fellowship (X.J.).